SCT Among Relatives of Sickle Cell Patients in Western Sudan

Author

By Munsoor M.Munsoor, Afaf Alabid.

Abstracts

This is an analytical hospital based study carried out in relatives of patients suffering from sickle cell disease (SCD) who referred to Elobied Hospital. The aim of this study was to estimate the frequency of sickle cell trait (HbAS) among those relatives and to assess their CBC. One hundred persons of seventeen different tribes were included (48% males and 52% females) with an age ranged between 4 to 70 years. From each person, 2.5 mL of venous blood was collected into EDTA container. Blood film, complete blood count (CBC) and sickling test were performed immediately. Then haemolysate was made and stored at ( 20 ◌C) for electrophoresis test. The results of hemoglobin electrophoresis show that, 54% of target samples were heterozygous carrier (HbAS) while 42% were normal (HbAA) and 4% were diagnosed as sickle cell disease (HbSS). The highest distribution of sickle cell trait was among Bederia tribe 9 (23.1%) followed by Fulani and Selehab 6 (15.4% for each tribe). The results of CBC show no significant difference in the values of haemoglobin (Hb) , haematocrite (HCT%), mean cell volume (MCV), mean cell hemoglobin (MCH), mean cell haemoglobin concentration (MCHC), red cell count (RBCs), white cell count (WBCs) and platelets count (Plt) between sickle cell trait (HbAS) and normal individuals (HbAA). This work concluded that members of the studied tribes are potentially capable for spreading of SCD in western Sudan

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